Robert Z Orlowski Selected Research

Leukemia

1/2019	Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma.
1/2016	The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: multiple myeloma, lymphoma, and acute leukemia.
9/2013	Biological effects of the Pim kinase inhibitor, SGI-1776, in multiple myeloma.
11/2004	Oral valacyclovir as prophylaxis against herpes simplex virus reactivation during high dose chemotherapy for leukemia.

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Robert Z Orlowski Research Topics

Disease

191	Multiple Myeloma 05/2024 - 11/2002
62	Neoplasms (Cancer) 04/2024 - 07/2002
22	Disease Progression 01/2024 - 11/2002
16	Hematologic Neoplasms (Hematological Malignancy) 11/2022 - 08/2002
12	Thrombocytopenia (Thrombopenia) 12/2018 - 11/2002
10	Breast Neoplasms (Breast Cancer) 12/2010 - 07/2002
9	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 11/2021 - 03/2008
9	Peripheral Nervous System Diseases (PNS Diseases) 10/2017 - 01/2006
8	Chromosome Aberrations (Chromosome Abnormalities) 04/2024 - 01/2006
7	Lymphoma (Lymphomas) 05/2016 - 04/2002
7	Non-Hodgkin Lymphoma (Lymphosarcoma) 11/2014 - 11/2002
6	Residual Neoplasm 01/2024 - 10/2016
6	Neutropenia 11/2021 - 12/2006
5	Plasmacytoma 12/2023 - 10/2011
5	Infections 01/2021 - 12/2004
5	Waldenstrom Macroglobulinemia (Macroglobulinemia) 01/2021 - 06/2015
5	Fatigue 10/2017 - 11/2002
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2023 - 10/2010
4	Pneumonia (Pneumonitis) 11/2021 - 01/2016
4	Paraproteinemias (Monoclonal Gammopathy) 01/2019 - 11/2002
4	Leukemia 01/2019 - 11/2004
3	Pain (Aches) 04/2022 - 04/2015
3	Carcinogenesis 01/2021 - 04/2002
3	Anemia 01/2019 - 10/2016
3	Vomiting 01/2018 - 12/2006
3	Nausea 01/2018 - 12/2006
3	Diarrhea 01/2018 - 12/2006
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2023 - 02/2015
2	Plasma Cell Neoplasms 11/2022 - 05/2013
2	Neoplasm Metastasis (Metastasis) 04/2022 - 08/2002
2	Lymphopenia (Lymphocytopenia) 11/2021 - 01/2019
2	Smoldering Multiple Myeloma 10/2020 - 01/2019
2	Mucositis 05/2019 - 06/2017
2	Plasma Cell Leukemia 01/2019 - 01/2019
2	Immunoglobulin Light-chain Amyloidosis 11/2018 - 08/2015
2	Hypertension (High Blood Pressure) 10/2017 - 01/2016

Drug/Important Bio-Agent (IBA)

86	Bortezomib (Velcade)FDA Link 04/2024 - 11/2002
48	Proteasome InhibitorsIBA 03/2024 - 11/2002
46	Dexamethasone (Maxidex)FDA LinkGeneric 04/2024 - 01/2006
43	Lenalidomide (CC 5013)FDA Link 04/2024 - 07/2006
25	Proteasome Endopeptidase Complex (Proteasome)IBA 11/2021 - 08/2002
19	carfilzomibIBA 11/2021 - 11/2007
13	daratumumabIBA 04/2024 - 04/2016
13	liposomal doxorubicin (Doxil)FDA Link 01/2017 - 04/2005
12	Proteins (Proteins, Gene)FDA Link 10/2023 - 11/2010
12	Melphalan (Alkeran)FDA LinkGeneric 01/2022 - 01/2006
11	Immunomodulating AgentsIBA 01/2021 - 01/2005
10	Monoclonal AntibodiesIBA 04/2023 - 12/2006
10	UbiquitinIBA 01/2019 - 01/2003
7	AnthracyclinesIBA 01/2017 - 12/2003
7	1-dodecylpyridoxal (PLD)IBA 07/2016 - 09/2007
6	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 09/2023 - 05/2008
6	Thalidomide (Thalomid)FDA Link 12/2019 - 07/2006
6	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2019 - 07/2002
6	Interleukin-6 (Interleukin 6)IBA 04/2015 - 11/2007
5	bis(3- bis(4- chlorophenyl)methyl- 4- dimethylaminophenyl)amineIBA 01/2024 - 01/2021
5	Biomarkers (Surrogate Marker)IBA 12/2023 - 12/2016
5	Histone Deacetylase InhibitorsIBA 12/2020 - 11/2009
5	siltuximabIBA 01/2015 - 11/2007
4	pomalidomideIBA 09/2023 - 03/2016
4	ParaproteinsIBA 01/2021 - 11/2002
4	PanobinostatIBA 01/2021 - 03/2015
4	Phosphotransferases (Kinase)IBA 01/2019 - 05/2007
3	B-Cell Maturation AntigenIBA 01/2024 - 11/2022
3	Immunoglobulins (Immunoglobulin)IBA 04/2023 - 03/2016
3	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2021 - 09/2015
3	EnzymesIBA 01/2019 - 11/2009
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2019 - 07/2002
3	p38 Mitogen-Activated Protein KinasesIBA 12/2017 - 11/2006
3	Rituximab (Mabthera)FDA Link 11/2014 - 12/2006
3	Prednisone (Sone)FDA LinkGeneric 06/2014 - 01/2006
2	RNA Polymerase II (RNA Polymerase B)IBA 01/2024 - 08/2017
2	Zoledronic Acid (Zometa)FDA Link 04/2022 - 06/2007
2	Diphosphonates (Bisphosphonates)IBA 04/2022 - 06/2007
2	ixazomibIBA 01/2022 - 01/2018
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2021 - 11/2009
2	elotuzumabIBA 01/2021 - 08/2015
2	Vorinostat FDA Link 12/2020 - 01/2017
2	Immunoglobulin G (IgG)IBA 01/2020 - 05/2016
2	CytokinesIBA 01/2020 - 12/2017
2	AntigensIBA 01/2020 - 11/2015
2	InterleukinsIBA 01/2020 - 03/2011
2	filanesibIBA 10/2019 - 12/2017
2	Busulfan (Busulfex)FDA Link 05/2019 - 06/2017
2	Protein Kinases (Protein Kinase)IBA 01/2019 - 09/2005
2	pembrolizumabIBA 01/2019 - 01/2019
2	alvocidib (flavopiridol)IBA 01/2018 - 08/2012
2	Apoptosis Regulatory ProteinsIBA 08/2017 - 01/2014
2	Transaminases (Aminotransferases)IBA 06/2017 - 01/2016
2	ARQ 197IBA 06/2017 - 03/2015

Therapy/Procedure

86	Therapeutics 04/2024 - 08/2002
21	Stem Cell Transplantation 05/2024 - 01/2006
17	Hematopoietic Stem Cell Transplantation 05/2024 - 03/2012
14	Drug Therapy (Chemotherapy) 11/2021 - 07/2002
6	Transplantation 10/2023 - 12/2018
5	Radiotherapy 12/2023 - 12/2003
4	Cell Transplantation 01/2023 - 08/2013
3	Autologous Transplantation 01/2024 - 01/2018
3	Drug Tapering 11/2015 - 07/2006
2	Retreatment 01/2021 - 10/2012